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Category:Video games developed in the United KingdomEffect of administration of intravenous lipid emulsion on the early changes in cardiac function during sepsis. Lipid emulsion is widely used for the treatment of patients with sepsis. However, there have been no reports on the effect of lipid emulsion on cardiac function during sepsis. We investigated the effect of intravenous lipid emulsion on cardiac function in rats with sepsis induced by cecal ligation and puncture. Sepsis was induced in rats by cecal ligation and puncture. The rats were randomly assigned to 4 groups (n=9 per group): a control group and 3 liposome groups (1 g/kg, 2 g/kg, and 4 g/kg). Treatment with the lipid emulsion was initiated at 1 hour after the cecal ligation and puncture and continued for 48 hours. Left ventricular systolic pressure (LVSP), mean arterial pressure (MAP), coronary blood flow (CBF), and lactate dehydrogenase (LDH) in the coronary effluent were measured before the cecal ligation and puncture and at 24 and 48 hours after the operation. We also assessed the hematocrit and white blood cell count, and used tissue plasminogen activator and plasminogen activator inhibitor to evaluate fibrinolysis and coagulation. Cardiac contractile function in the 3 liposome groups was improved compared with that in the control group at 24 hours after the operation. No significant differences in cardiac contractile function were observed between the control group and the 1 g/kg and 2 g/kg liposome groups at 48 hours after the operation. Lactate dehydrogenase activity in the coronary effluent in the liposome groups was lower than that in the control group at 24 hours after the operation. Lactate dehydrogenase activity in the coronary effluent in the liposome groups was higher than that in the control group at 48 hours after the operation. There were no significant differences in hematocrit and white blood cell count among the 4 groups. Tissue plasminogen activator and plasminogen activator inhibitor levels in the liposome groups at 24 and 48 hours after the operation were not significantly different from those in the control group. Intravenous lipid emulsion improves cardiac contractile function in the early phase of sepsis./* * Copyright (C



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